Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteogenomic identification of Hepatitis B virus (HBV) genotype-specific HLA-I restricted peptides from HBV-positive patient liver tissues.

Frontiers in immunology - 1 Jan 2022

Srivastava Mayank, Copin Richard, Choy Augustine, Zhou Anbo, Olsen Olav, Wolf Sarah, Shah Darshit, Rye-Weller Anna, Chen Lisa, Chan Newton, Coppola Angel, Lanza Kathryn, Negron Nicole, Ni Min, Atwal Gurinder S, Kyratsous Christos A, Olson William, Salzler Robert

Abstract excerpt

The presentation of virus-derived peptides by HLA class I molecules on the surface of an infected cell and the recognition of these HLA-peptide complexes by, and subsequent activation of, CD8+ cytotoxic T cells provides an important mechanism for immune protection against viruses. Recent advances in proteogenomics have allowed researchers to discover a growing number of unique HLA-restricted viral peptides,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Hepatitis B virus

Share to Liver Neoplasms

Share to Peptides

Share to Proteogenomics

Source

Open in PubMed Open full text

Identifiers

PMID: 36582233
DOI: 10.3389/fimmu.2022.1032716
PMCID: PMC9793402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteogenomic identification of Hepatitis B virus (HBV) genotype-specific HLA-I restricted peptides from HBV-positive patient liver tissues.PMID 36582233Read ↗

A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics.Semantic proximity Read ↗

Proteomic Signatures of Hepatitis B Virus Mutations Reveal Genotype-Specific Host Responses and Biomarker CandidatesSemantic proximity Read ↗

Rational Design of a Multiepitope Vaccine Encoding T-Lymphocyte Epitopes for Treatment of Chronic Hepatitis B Virus InfectionsSemantic proximity Read ↗

Machine-learning based patient classification using Hepatitis B virus full-length genome quasispecies from Asian and European cohorts.Semantic proximity Read ↗

Detecting tumor-associated peptides from the plasma-derived soluble immunopeptidome in human hepatocellular carcinoma patients: a pilot studySemantic proximity Read ↗

A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes.Semantic proximity Read ↗

Discovery and Selection of Hepatitis B Virus-Derived T Cell Epitopes for Global Immunotherapy Based on Viral Indispensability, Conservation, and HLA-Binding Strength.Semantic proximity Read ↗

Current perspectives on mass spectrometry-based immunopeptidomics: the computational angle to tumor antigen discoverySemantic proximity Read ↗

Mass Spectrometry-Based Profiling of Personalized Immunopeptidomes in Thai Renal Cell CarcinomaSemantic proximity Read ↗

An in silico—in vitro Pipeline Identifying an HLA-A*02:01+ KRAS G12V+ Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer PatientsSemantic proximity Read ↗

Immuno-proteomic interrogation of dengue infection reveals novel HLA haplotype-specific MHC-I antigensSemantic proximity Read ↗

Mass spectrometry based immunopeptidomics leads to robust predictions of phosphorylated HLA class I ligandsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.