Article
Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma.
Cell reports - 17 Dec 2019
Aiello Giuseppe, Ballabio Claudio, Ruggeri Riccardo, Fagnocchi Luca, Anderle Marica, Morassut Ilaria, Caron Davide, Garilli Francesca, Gianno Francesca, Giangaspero Felice, Piazza Silvano, Romanel Alessandro, Zippo Alessio, Tiberi Luca
Abstract excerpt
The transition of neural progenitors to differentiated postmitotic neurons is mainly considered irreversible in physiological conditions. In the present work, we show that Shh pathway activation through SmoM2 expression promotes postmitotic neurons dedifferentiation, re-entering in the cell cycle and originating medulloblastoma in vivo. Notably, human adult patients present inactivating mutations of the chromatin...
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