Article
Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation.
Genes & development - 1 Sept 2020
Kutscher Lena M, Okonechnikov Konstantin, Batora Nadja V, Clark Jessica, Silva Patricia B G, Vouri Mikaella, van Rijn Sjoerd, Sieber Laura, Statz Britta, Gearhart Micah D, Shiraishi Ryo, Mack Norman, Orr Brent A, Korshunov Andrey, Gudenas Brian L, Smith Kyle S, Mercier Audrey L, Ayrault Olivier, Hoshino Mikio, Kool Marcel, von Hoff Katja, Graf Norbert, Fleischhack Gudrun, Bardwell Vivian J, Pfister Stefan M, Northcott Paul A, Kawauchi Daisuke
Abstract excerpt
Medulloblastoma is a malignant childhood brain tumor arising from the developing cerebellum. In Sonic Hedgehog (SHH) subgroup medulloblastoma, aberrant activation of SHH signaling causes increased proliferation of granule neuron progenitors (GNPs), and predisposes these cells to tumorigenesis. A second, cooperating genetic hit is often required to push these hyperplastic cells to malignancy and confer...
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