Article
A potential role for insulin resistance in experimental pulmonary hypertension.
The European respiratory journal - 1 Apr 2013
West James, Niswender Kevin D, Johnson Jennifer A, Pugh Meredith E, Gleaves Linda, Fessel Joshua P, Hemnes Anna R
Abstract excerpt
Patients with pulmonary arterial hypertension have increased prevalence of insulin resistance. We aimed to determine whether metabolic defects are associated with bone morphogenic protein receptor type 2 (Bmpr2) mutations in mice, and whether these may contribute to pulmonary vascular disease development. Metabolic phenotyping was performed on transgenic mice with inducible expression of Bmpr2 mutation, R899X....
Topics
- Animals
- Body Composition
- Bone Morphogenetic Protein Receptors, Type II
- Cell Line
- Dexamethasone
- Diet, High-Fat
- Disease Models, Animal
- Energy Metabolism
- Humans
- Hypertension, Pulmonary