Article

Nutrient-dependent pathology in mitochondrial hypertrophic cardiomyopathy model

2025-09-26

Abstract excerpt

<h4>Objective</h4> Mitochondrial translation defects are a major cause of early childhood hypertrophic cardiomyopathy (CMP). While the genetic basis of these disorders is being increasingly uncovered, the downstream molecular mechanisms driving disease pathogenesis remain poorly understood. In this study, we investigated the consequences of defects in mitochondrial ribosomal large subunit protein 44 (MRPL44), ass...

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Literature Corpus work: 2a6b68b3-ca20-5eea-af26-cfc1d7a04220
DOI: 10.1101/2025.09.24.678132

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