Plasma membrane order maps functional diversity in immune cells

Abstract excerpt

Cell membranes undergo biophysical remodelling as an adaptation to the surroundings and to perform specific biological functions. However, the extent and relevance of such changes in human immune cells remain unknown, largely due to the lack of single-cell and multidimensional methodologies. Here, we apply a cytometry-based method to fill this gap by combining biophysical profiling with simultaneous analysis of im...

Topics

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• Gene Expression Regulation
• Genetic Heterogeneity
• Immune System
• Immunity
• Phenotype
• Single-cell and spatial transcriptomics
• Systemic Lupus Erythematosus Research
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

6361139a-40dd-529a-8a2c-c4717a717a78

DOI

10.1101/2024.01.15.575649