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Article

Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245.

Blood - 10 Dec 2009

Bari Rafijul, Bell Teresa, Leung Wai-Hang, Vong Queenie P, Chan Wing Keung, Das Gupta Neha, Holladay Martha, Rooney Barbara, Leung Wing

Abstract excerpt

Killer immunoglobulin-like receptors (KIRs) play an essential role in the regulation of natural killer cell functions. KIR genes are highly polymorphic in nature, showing both haplotypic and allelic variations among people. We demonstrated in both in vitro and in vivo models a significant heterogeneity in function among different KIR2DL1 alleles, including their ability to inhibit YT-Indy cells from...

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Identifiers

PMID: 19828694
DOI: 10.1182/blood-2009-07-231977
PMCID: PMC2792213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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