Article
Mate pair sequencing outperforms fluorescence in situ hybridization in the genomic characterization of multiple myeloma.
Blood cancer journal - 16 Dec 2019
Smadbeck James, Peterson Jess F, Pearce Kathryn E, Pitel Beth A, Figueroa Andrea Lebron, Timm Michael, Jevremovic Dragan, Shi Min, Stewart A Keith, Braggio Esteban, Riggs Daniel L, Bergsagel P Leif, Vasmatzis George, Kearney Hutton M, Hoppman Nicole L, Ketterling Rhett P, Kumar Shaji, Rajkumar S Vincent, Greipp Patricia T, Baughn Linda B
Abstract excerpt
Fluorescence in situ hybridization (FISH) is currently the gold-standard assay to detect recurrent genomic abnormalities of prognostic significance in multiple myeloma (MM). Since most translocations in MM involve a position effect with heterogeneous breakpoints, we hypothesize that FISH has the potential to miss translocations involving these regions. We evaluated 70 bone marrow samples from patients with plasma...
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