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Mate pair sequencing improves detection of genomic abnormalities in acute myeloid leukemia

1 Oct 2018

Abstract excerpt

OBJECTIVE: Acute myeloid leukemia (AML) can be subtyped based on recurrent cytogenetic and molecular genetic abnormalities with diagnostic and prognostic significance. Although cytogenetic characterization classically involves conventional chromosome and/or fluorescence in situ hybridization (FISH) assays, limitations of these techniques include poor resolution and the inability to precisely identify breakpoints....

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PMID: 30270457
DOI: 10.1111/ejh.13179

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