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Chromosomal defects in multiple myeloma

4 Jan 2024

Abstract excerpt

Multiple myeloma is a plasma cell neoplasm driven by primary (e.g. hyperdiploidy; IGH translocations) and secondary (e.g. 1q21 gains/amplifications; del(17p); MYC translocations) chromosomal events. These are important to detect as they influence prognosis, therapeutic response and disease survival. Currently, cytogenetic testing is most commonly performed by interphase fluorescence in situ hybridisation (FISH)...

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PMID: 38212176
DOI: 10.1016/j.blre.2024.101168

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