Circulating Tumor DNA Analysis for Patients with Oncogene-Addicted NSCLC With Isolated Central Nervous System Progression.

doi:10.1016/j.jtho.2019.11.024

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Article

Circulating Tumor DNA Analysis for Patients with Oncogene-Addicted NSCLC With Isolated Central Nervous System Progression.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2020

Aldea Mihaela, Hendriks Lizza, Mezquita Laura, Jovelet Cécile, Planchard David, Auclin Edouard, Remon Jordi, Howarth Karen, Benitez Jose Carlos, Gazzah Anas, Lavaud Pernelle, Naltet Charles, Lacroix Ludovic, de Kievit Frank, Morris Clive, Green Emma, Ngo-Camus Maud, Rouleau Etienne, Massard Christophe, Caramella Caroline, Friboulet Luc, Besse Benjamin

Abstract excerpt

INTRODUCTION: In patients with oncogene-addicted NSCLC and isolated central nervous system progression (iCNS), tissue biopsy is challenging, and the clinical utility of plasma liquid biopsy (i.e., circulating tumor DNA [ctDNA]) is unknown. METHODS: Patients with advanced NSCLC with known baseline genomic alteration (GA) (EGFR, ALK, BRAF, KRAS, HER2, ROS1, MET, PIK3CA, STK11, TP53) on tissue were divided into...

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PMID: 31843682
DOI: 10.1016/j.jtho.2019.11.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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