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Article

Deconvoluting the diversity of within-host pathogen strains in a multi-locus sequence typing framework.

BMC bioinformatics - 17 Dec 2019

Gan Guo Liang, Willie Elijah, Chauve Cedric, Chindelevitch Leonid

Abstract excerpt

BACKGROUND: Bacterial pathogens exhibit an impressive amount of genomic diversity. This diversity can be informative of evolutionary adaptations, host-pathogen interactions, and disease transmission patterns. However, capturing this diversity directly from biological samples is challenging. RESULTS: We introduce a framework for understanding the within-host diversity of a pathogen using multi-locus sequence types...

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Identifiers

PMID: 31842753
DOI: 10.1186/s12859-019-3204-8
PMCID: PMC6915855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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