Inferring Strain Mixture within Clinical Plasmodium falciparum Isolates from Genomic Sequence Data.

Abstract excerpt

We present a rigorous statistical model that infers the structure of P. falciparum mixtures-including the number of strains present, their proportion within the samples, and the amount of unexplained mixture-using whole genome sequence (WGS) data. Applied to simulation data, artificial laboratory mixtures, and field samples, the model provides reasonable inference with as few as 10 reads or 50 SNPs and works...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Bayes Theorem
• Share to Chromosome Mapping