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Article

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.

Nature communications - 12 Jan 2015

Devlin Anna-Claire, Burr Karen, Borooah Shyamanga, Foster Joshua D, Cleary Elaine M, Geti Imbisaat, Vallier Ludovic, Shaw Christopher E, Chandran Siddharthan, Miles Gareth B

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which a greater understanding of early disease mechanisms is needed to reveal novel therapeutic targets. We report the use of human induced pluripotent stem cell (iPSC)-derived motoneurons (MNs) to study the pathophysiology of ALS. We demonstrate that MNs derived from iPSCs obtained from healthy individuals or patients harbouring...

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Identifiers

PMID: 25580746
DOI: 10.1038/ncomms6999
PMCID: PMC4338554

Genes

TARDBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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