Article

Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding

2021-01-08

Abstract excerpt

<title>Abstract</title> <p>Malaria during pregnancy remains a major health problem in Plasmodium falciparum endemic areas. Parasite-infected red blood cells sequester in the placenta through interaction between parasite-expressed protein VAR2CSA and the glycosaminoglycan chondroitin sulfate A (CS) abundantly present in the intervillous space. Placental malaria can have severe consequences for both mother and chil...

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Literature Corpus work: 52f43b6e-0bf0-523f-9c58-a31effd2e0f5
DOI: 10.21203/rs.3.rs-121821/v1

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