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Article

Convergent microevolution of Cryptococcus neoformans hypervirulence in the laboratory and the clinic.

Scientific reports - 20 Dec 2017

Arras Samantha D M, Ormerod Kate L, Erpf Paige E, Espinosa Monica I, Carpenter Alex C, Blundell Ross D, Stowasser Samantha R, Schulz Benjamin L, Tanurdzic Milos, Fraser James A

Abstract excerpt

Reference strains are a key component of laboratory research, providing a common background allowing for comparisons across a community of researchers. However, laboratory passage of these strains has been shown to lead to reduced fitness and the attenuation of virulence in some species. In this study we show the opposite in the fungal pathogen Cryptococcus neoformans, with analysis of a collection of type strain...

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Identifiers

PMID: 29263343
DOI: 10.1038/s41598-017-18106-2
PMCID: PMC5738413

Genes

SGF29

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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