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Article

Inhibition of XBP1s ubiquitination enhances its protein stability and improves glucose homeostasis.

Metabolism: clinical and experimental - 1 Apr 2020

Sun Honglin, Wei Gang, Liu He, Xiao Danrui, Huang Jianbo, Lu Junxi, Miao Ji, Liu Junli, Chen Suzhen

Abstract excerpt

BACKGROUND: Hepatic ER stress is a risk factor of insulin resistance and type 2 diabetes. X-box binding protein 1 spliced (XBP1s), a transcription factor, plays a key role in ameliorating insulin resistance and maintaining glucose homeostasis. Unfortunately, the short half-life of the protein dampens its clinical application, and the specific site of lysine residue that could be ubiquitinated and involved in the...

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Share to Diet, High-Fat
Share to Endoplasmic Reticulum Stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O1

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Share to Translocation, Genetic

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Source

Identifiers

PMID: 31837300
DOI: 10.1016/j.metabol.2019.154046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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