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Article

X‐box binding protein 1 (XBP1) function in diseases

16 Dec 2020

Abstract excerpt

The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) causes endoplasmic reticulum stress (ERS), which is characteristic of cells with high levels of secretory activity and is involved in a variety of diseases. In response to ERS, cells initiate an adaptive process named the unfolding protein response (UPR) to maintain intracellular homeostasis and survival. However, long term and...

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PMID: 33325615
DOI: 10.1002/cbin.11533

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