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Article

UBC9 regulates the stability of XBP1, a key transcription factor controlling the ER stress response.

Cell structure and function - 1 Jan 2013

Uemura Aya, Taniguchi Mai, Matsuo Yusaku, Oku Masaya, Wakabayashi Sadao, Yoshida Hiderou

Abstract excerpt

XBP1 is a key transcription factor regulating the mammalian endoplasmic reticulum (ER) stress response, which is a cytoprotective mechanism for dealing with an accumulation of unfolded proteins in the ER (ER stress). The expression of XBP1 is regulated by two different mechanisms: mRNA splicing and protein stability. When ER stress occurs, unspliced XBP1 mRNA is converted to mature mRNA, from which an active...

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Share to Endoplasmic Reticulum Stress
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Regulatory Factor X Transcription Factors

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Source

Identifiers

PMID: 23470653
DOI: 10.1247/csf.12026

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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