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Article

Emerging Roles for XBP1, a sUPeR Transcription Factor

1 Jan 2010

Abstract excerpt

X-box binding protein 1 (XBP1) is a unique basic region leucine zipper (bZIP) transcription factor whose active form is generated by a nonconventional splicing reaction upon disruption of homeostasis in the endoplasmic reticulum (ER) and activation of the unfolded protein response (UPR). XBP1, first identified as a key regulator of major histocompatibility complex (MHC) class II gene expression in B cells,...

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PMID: 21061914
DOI: 10.3727/105221610x12819686555051

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