Xbp1 targets canonical UPRER and non-canonical pathways in separate tissues to promote longevity

Abstract excerpt

Transcription factors can reprogram gene expression to promote longevity. Here, we investigate the role of Drosophila Xbp1. Xbp1 is activated by splicing of its primary transcript, Xbp1 u , to generate Xbp1 s , a key activator of the endoplasmic reticulum unfolded protein response (UPR ER ). We show that Xbp1 s induces the conical UPR ER in the gut, promoting longevity from the resident stem cells. In contrast,...

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