Article
Clinico-neuropathological features of isocitrate dehydrogenase 2 gene mutations in lower-grade gliomas.
Chinese medical journal - 20 Dec 2019
Wang Lei-Ming, Li Zhuo, Piao Yue-Shan, Cai Yan-Ning, Zhang Li-Yan, Ge Hai-Jing, Xu Wei-Wei, Lu De-Hong
Abstract excerpt
BACKGROUND: Mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes are important for both the integrated diagnosis and the prognosis of diffuse gliomas. The p.R132H mutation of IDH1 is the most frequently observed IDH mutation, while IDH2 mutations were relatively rarely studied. The aim of the study was to determine the pathological and genetic characteristics of lower-grade gliomas that carry IDH2...
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