Article

A new clustering approach identifies tumor-specific common TCRs with pan-cancer reactivity

2025-04-30

Abstract excerpt

Tumor-specific T-cells are key in combating cancer as shown in adoptive cell therapy with tumor infiltrating lymphocytes (TILs) and checkpoint inhibitor therapy. Studies in many types of cancer have shown that preexisting tumor reactive T-cells are not only tumor-but typically also patient-specific, requiring personalized treatment options. For viral infections, public T-cell receptors (TCRs) with substantial sequ...

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Identifiers and source

Literature Corpus work: a2789874-1199-5919-8b59-00a6da22e0c0
DOI: 10.1101/2025.04.26.650660

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