Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21.

PLoS genetics - 1 Dec 2019

Chernus Jonathan M, Allen Emily G, Zeng Zhen, Hoffman Eva R, Hassold Terry J, Feingold Eleanor, Sherman Stephanie L

Abstract excerpt

Human nondisjunction errors in oocytes are the leading cause of pregnancy loss, and for pregnancies that continue to term, the leading cause of intellectual disabilities and birth defects. For the first time, we have conducted a candidate gene and genome-wide association study to identify genes associated with maternal nondisjunction of chromosome 21 as a first step to understand predisposing factors. A total of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cation Transport Proteins
Share to Down Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Meiosis

Share to Mothers

Share to Nondisjunction, Genetic

Share to Oocytes

Share to United States

Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 31830031
DOI: 10.1371/journal.pgen.1008414
PMCID: PMC6932832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21.PMID 31830031Read ↗

New Insights into Human Nondisjunction of Chromosome 21 in OocytesSemantic proximity Read ↗

Nondisjunction in trisomy 21: Origin and mechanismsSemantic proximity Read ↗

Altered patterns of multiple recombinant events are associated with nondisjunction of chromosome 21.Semantic proximity Read ↗

Maternal meiosis II nondisjunction in trisomy 21 is associated with maternal low socioeconomic statusSemantic proximity Read ↗

Risk factors for nondisjunction of trisomy 21Semantic proximity Read ↗

Understanding Etiology of Chromosome 21 Nondisjunction from Gene X Environment ModelsSemantic proximity Read ↗

The etiology of Down syndrome: Maternal MCM9 polymorphisms increase risk of reduced recombination and nondisjunction of chromosome 21 during meiosis I within oocyte.Semantic proximity Read ↗

An examination of the relationship between hotspots and recombination associated with chromosome 21 nondisjunction.Semantic proximity Read ↗

Etiology of nondisjunction in humansSemantic proximity Read ↗

Understanding etiology of chromosome 21 nondisjunction from gene × environment models.Semantic proximity Read ↗

A Pair of Maternal Chromosomes Derived from Meiotic Nondisjunction in Trisomy 21 Affects Nuclear Architecture and Transcriptional Regulation.Semantic proximity Read ↗

Investigation of factors associated with paternal nondisjunction of chromosome 21.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.