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Article

Altered patterns of multiple recombinant events are associated with nondisjunction of chromosome 21.

Human genetics - 1 Jul 2012

Oliver Tiffany Renee, Tinker Stuart W, Allen Emily Graves, Hollis Natasha, Locke Adam E, Bean Lora J H, Chowdhury Reshmi, Begum Ferdouse, Marazita Mary, Cheung Vivian, Feingold Eleanor, Sherman Stephanie L

Abstract excerpt

We have previously examined characteristics of maternal chromosomes 21 that exhibited a single recombination on 21q and proposed that certain recombination configurations are risk factors for either meiosis I (MI) or meiosis II (MII) nondisjunction. The primary goal of this analysis was to examine characteristics of maternal chromosomes 21 that exhibited multiple recombinant events on 21q to determine whether...

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Share to Chromosomes, Human, Pair 21
Share to Genomic variations and chromosomal abnormalities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Maternal Age

Share to Meiosis

Share to Nondisjunction, Genetic

Share to Polymorphism, Single Nucleotide

Share to Recombination, Genetic

Source

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Identifiers

PMID: 22160426
DOI: 10.1007/s00439-011-1121-7
PMCID: PMC3925977

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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