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Article

Understanding etiology of chromosome 21 nondisjunction from gene × environment models.

Scientific reports - 17 Nov 2021

Halder Pinku, Pal Upamanyu, Ganguly Agnish, Ghosh Papiya, Ray Anirban, Sarkar Sumantra, Ghosh Sujay

Abstract excerpt

Maternal risk factors and their interactions with each other that associate chromosome 21 nondisjunction are intriguing and need incisive study to be resolved. We determined recombination profile of nondisjoined chromosome 21 and maternal genotypes for four selected polymorphic variants from the folate regulators genes stratifying the women according to the origin of segregation error and age at conception. We...

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Share to Recombination, Genetic
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Down Syndrome

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Share to Maternal Exposure

Share to Nondisjunction, Genetic

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Source

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Identifiers

PMID: 34789805
DOI: 10.1038/s41598-021-01672-x
PMCID: PMC8599692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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