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Article

An examination of the relationship between hotspots and recombination associated with chromosome 21 nondisjunction.

PloS one - 1 Jan 2014

Oliver Tiffany Renee, Middlebrooks Candace D, Tinker Stuart W, Allen Emily Graves, Bean Lora J H, Begum Ferdouse, Feingold Eleanor, Chowdhury Reshmi, Cheung Vivian, Sherman Stephanie L

Abstract excerpt

Trisomy 21, resulting in Down Syndrome (DS), is the most common autosomal trisomy among live-born infants and is caused mainly by nondisjunction of chromosome 21 within oocytes. Risk factors for nondisjunction depend on the parental origin and type of meiotic error. For errors in the oocyte, incr...

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Share to Chromosomes, Human, Pair 21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24926858
DOI: 10.1371/journal.pone.0099560
PMCID: PMC4057233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24926858-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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