Article
A Pair of Maternal Chromosomes Derived from Meiotic Nondisjunction in Trisomy 21 Affects Nuclear Architecture and Transcriptional Regulation.
Scientific reports - 10 Apr 2017
Omori Sayaka, Tanabe Hideyuki, Banno Kimihiko, Tsuji Ayumi, Nawa Nobutoshi, Hirata Katsuya, Kawatani Keiji, Kokubu Chikara, Takeda Junji, Taniguchi Hidetoshi, Arahori Hitomi, Wada Kazuko, Kitabatake Yasuji, Ozono Keiichi
Abstract excerpt
Eukaryotic genomes are organised into complex higher-order structures within the nucleus, and the three-dimensional arrangement of chromosomes is functionally important for global gene regulation. The existence of supernumerary chromosome 21 in Down syndrome may perturb the nuclear architecture at different levels, which is normally optimised to maintain the physiological balance of gene expression. However, it...
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