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Article

Genetic Interactions and Tissue Specificity Modulate the Association of Mutations with Drug Response.

Molecular cancer therapeutics - 1 Mar 2020

Cramer Dina, Mazur Johanna, Espinosa Octavio, Schlesner Matthias, Hübschmann Daniel, Eils Roland, Staub Eike

Abstract excerpt

In oncology, biomarkers are widely used to predict subgroups of patients that respond to a given drug. Although clinical decisions often rely on single gene biomarkers, machine learning approaches tend to generate complex multi-gene biomarkers that are hard to interpret. Models predicting drug response based on multiple altered genes often assume that the effects of single alterations are independent. We asked...

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PMID: 31826931
DOI: 10.1158/1535-7163.MCT-19-0045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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