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Article

Single nucleotide and copy number variants of cancer driver genes inform drug response in multiple cancers.

PloS one - 1 Jan 2024

Wang Zeyuan, Gu Hong, Qin Pan, Wang Jia

Abstract excerpt

Due to the heterogeneity of cancer, precision medicine has been a major challenge for cancer treatment. Determining medication regimens based on patient genotypes has become a research hotspot in cancer genomics. In this study, we aim to identify key biomarkers for targeted therapies based on single nucleotide variants (SNVs) and copy number variants (CNVs) of genes. The experiment is carried out on 7 cancers on...

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Antineoplastic Agents
Biomarkers, Tumor
Cell Line, Tumor
DNA Copy Number Variations
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Precision Medicine

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Identifiers

PMID: 39083502
DOI: 10.1371/journal.pone.0306343
PMCID: PMC11290640

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