Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Large-Scale Exome-Wide Association Study Identifies Novel Germline Mutations in Lung Cancer.

American journal of respiratory and critical care medicine - 1 Aug 2023

Shen Sipeng, Li Zaiming, Jiang Yunke, Duan Weiwei, Li Hongru, Du Sha, Esteller Manel, Shen Hongbing, Hu Zhibin, Zhao Yang, Christiani David C, Chen Feng

Abstract excerpt

Rationale: Genome-wide association studies have identified common variants of lung cancer. However, the contribution of rare exome-wide variants, especially protein-coding variants, to cancers remains largely unexplored. Objectives: To evaluate the role of human exomes in genetic predisposition to lung cancer. Methods: We performed exome-wide association studies to detect the association of exomes with lung...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Exome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RTEL1 gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Germ-Line Mutation

Share to Lung Neoplasms

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 37167549
DOI: 10.1164/rccm.202212-2199OC
PMCID: PMC10395715

Genes

BSG
POT1
RTEL1
ZNF232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Large-Scale Exome-Wide Association Study Identifies Novel Germline Mutations in Lung Cancer.PMID 37167549Read ↗

Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p, and 4q.Semantic proximity Read ↗

An Exome Sequencing Study to Assess the Role of Rare Genetic Variation in Pulmonary Fibrosis.Semantic proximity Read ↗

Germline determinants of risk and molecular subtype in young-onset lung cancerSemantic proximity Read ↗

Rare germline deleterious variants increase susceptibility for lung cancer.Semantic proximity Read ↗

Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer.Semantic proximity Read ↗

Whole-exome sequencing analysis of NSCLC reveals the pathogenic missense variants from cancer-associated genes.Semantic proximity Read ↗

Genome-wide meta-analysis across East Asian and European populations provides insights into the molecular basis of lung cancer.Semantic proximity Read ↗

Somatic mutations in chronic lung disease are associated with reduced lung functionSemantic proximity Read ↗

Whole-exome sequencing reveals genetic variability among lung cancer cases subphenotyped for emphysema.Semantic proximity Read ↗

Complex genetics of pulmonary diseases: lessons from genome-wide association studies and next-generation sequencing.Semantic proximity Read ↗

Inherited genetic risk factors in young-onset lung cancerSemantic proximity Read ↗

Genetic analysis of lung cancer reveals novel susceptibility loci and germline impact on somatic mutation burdenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.