Article

Monocyte Metabolic Plasticity and Cytokine Production Differentiate Latent TB Infection from Active Disease

2025-04-26

Abstract excerpt

<h4>Rationale</h4> Monocytes are central to host defence against Mycobacterium tuberculosis (Mtb), yet their functional and metabolic profiles during latent TB infection (TBI) and active TB disease (TBD) remain poorly defined. Immunometabolic dysfunction may underlie ineffective responses in TB, but cell-specific mechanisms are unclear. <h4>Objectives</h4> To compare the phenotypic, functional, and metabolic p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbdbf65b-d972-5362-9e49-f166c4f401a6
DOI: 10.1101/2025.04.24.650431

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Monocyte Metabolic Plasticity and Cytokine Production Differentiate Latent TB Infection from Active DiseaseDOI 10.1101/2025.04.24.650431Read

Elevated glycolytic metabolism of monocytes limits the generation of HIF-1α-driven migratory dendritic cells in tuberculosisSemantic proximity Read

Monocyte transcriptome signatures of inflammation and enhanced neutrophil recruitment characterize immunopathology in the blood of tuberculosis patientsSemantic proximity Read

Single-cell profiling reveals distinct subsets of CD14+ monocytes drive blood immune signatures of active tuberculosisSemantic proximity Read

Monocyte Subsets: Phenotypes and Function in Tuberculosis Infection.Semantic proximity Read

Exploring T-cell metabolism in tuberculosis: development of a diagnostic model using metabolic genesSemantic proximity Read

Beyond the Clinic: The Activation of Diverse Cellular and Humoral Factors Shapes the Immunological Status of Patients with Active TuberculosisSemantic proximity Read

Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responsesSemantic proximity Read

Peripheral blood cellular dynamics during the progression of human tuberculosisSemantic proximity Read

Compromised Metabolic Reprogramming Is an Early Indicator of CD8+ T Cell Dysfunction during Chronic Mycobacterium tuberculosis InfectionSemantic proximity Read

Multimodal profiling reveals <i>Mycobacterium tuberculosis</i> restricts lung mitochondrial immunometabolism to promote pathogenesisSemantic proximity Read

Infection of Monocytes From Tuberculosis Patients With Two Virulent Clinical Isolates of Mycobacterium tuberculosis Induces Alterations in Myeloid Effector FunctionsSemantic proximity Read

Lactate Metabolism and Signaling in Tuberculosis and Cancer: A Comparative ReviewSemantic proximity Read