Article
Pannexin 3 ER Ca2+ channel gating is regulated by phosphorylation at the Serine 68 residue in osteoblast differentiation.
Scientific reports - 10 Dec 2019
Ishikawa Masaki, Williams Geneva, Forcinito Patricia, Ishikawa Momoko, Petrie Ryan J, Saito Kan, Fukumoto Satoshi, Yamada Yoshihiko
Abstract excerpt
Pannexin 3 (Panx3) is a regulator of bone formation. Panx3 forms three distinct functional channels: hemichannels, gap junctions, and endoplasmic reticulum (ER) Ca2+ channels. However, the gating mechanisms of the Panx3 channels remain unclear. Here, we show that the Panx3 ER Ca2+ channel is modulated by phosphorylation of the serine 68 residue (Ser68) to promote osteoblast differentiation. Among the 17 candidate...
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