Article
Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease.
Nature communications - 11 Dec 2019
Tsukiyama Tomoyuki, Kobayashi Kenichi, Nakaya Masataka, Iwatani Chizuru, Seita Yasunari, Tsuchiya Hideaki, Matsushita Jun, Kitajima Kahoru, Kawamoto Ikuo, Nakagawa Takahiro, Fukuda Koji, Iwakiri Teppei, Izumi Hiroyuki, Itagaki Iori, Kume Shinji, Maegawa Hiroshi, Nishinakamura Ryuichi, Nishio Saori, Nakamura Shinichiro, Kawauchi Akihiro, Ema Masatsugu
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) caused by PKD1 mutations is one of the most common hereditary disorders. However, the key pathological processes underlying cyst development and exacerbation in pre-symptomatic stages remain unknown, because rodent models do not recapitulate critical disease phenotypes, including disease onset in heterozygotes. Here, using CRISPR/Cas9, we generate ADPKD models...
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