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Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases.

Clinical rheumatology - 1 May 2016

Umeda Naoto, Matsumoto Isao, Kawaguchi Hoshimi, Kurashima Yuko, Kondo Yuya, Tsuboi Hiroto, Ogishima Hiroshi, Suzuki Takeshi, Kagami Yayoi, Sakyu Takuya, Ishigami Akihito, Maruyama Naoki, Sumida Takayuki

Abstract excerpt

The objectives of this study are to investigate the prevalence of PAD4 and anti-PAD4 antibodies (Abs) in autoimmune diseases and to clarify their association with anticitrullinated protein antibodies (ACPAs) and shared epitope (SE) in patients with rheumatoid arthritis (RA). Levels of human PAD4 and anti-PAD4 Abs in serum or plasma were measured using sandwich ELISA. Samples were obtained from patients with RA...

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PMID: 26415740
DOI: 10.1007/s10067-015-3082-z

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