Article
Citrullinated proteins in rheumatoid arthritis.
Frontiers in bioscience : a journal and virtual library - 1 Jan 2005
Yamada Ryo, Suzuki Akari, Chang Xiaotian, Yamamoto Kazuhiko
Abstract excerpt
Citrullinated proteins that are produced by enzymatic deimination of arginine residues in proteins by peptidylarginine deiminases (PADIs) are of particular interest in the pathogenesis of rheumatoid arthritis (RA). First, peptidylarginine deiminase type 4 (PADI4) gene, which codes one of the PADI enzyme isotypes, has a genetic variant that increases susceptibility to RA. The RA-susceptible variant of PADI4 seems...
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