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Article

Immunity to Citrullinated Proteins in Rheumatoid Arthritis

3 Jan 2008

Abstract excerpt

Antibodies to citrullinated proteins (ACPA), i.e., to peptides posttranslationally modified by the conversion of arginine to citrulline, are specific serological markers for rheumatoid arthritis (RA). Studies on anticitrulline immunity, summarized in this review, demonstrate that the criterion-based syndrome RA should be subdivided into at least two distinct subsets (ACPA-positive and ACPA-negative disease). A...

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PMID: 18173373
DOI: 10.1146/annurev.immunol.26.021607.090244

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