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Article

PAD2 immunization induces ACPA in wild-type and HLA-DR4 humanized mice.

European journal of immunology - 1 Sept 2022

Hemon Marie F, Lambert Nathalie C, Roudier Jean, Auger Isabelle

Abstract excerpt

Rheumatoid arthritis (RA) is associated with HLA-DRB1 alleles expressing the "shared epitope." RA is usually preceded by the emergence of anti-citrullinated protein autoantibodies (ACPAs). ACPAs recognize citrulline residues on numerous proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs). We have previously demonstrated that C3H mice immunized with...

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Share to Arginine
Share to Arthritis, Rheumatoid
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Citrulline

Share to HLA-DR4 Antigen

Share to HLA-DRB1 Chains

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Share to Mice, Inbred C3H

Source

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Identifiers

PMID: 35712879
DOI: 10.1002/eji.202249889
PMCID: PMC9545684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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