Exploring the Correlation Between Genotypes of Drug-Metabolizing Enzymes and the Therapeutic Efficacy and Adverse Reactions of Cyclophosphamide in Childhood-Onset Lupus Nephritis: A Chinese Cohort Study.

Abstract excerpt

OBJECTIVE: To investigate the association between genetic polymorphisms (CYP2B6, CYP2C19, GSTP1) and haplotypes of cyclophosphamide (CTX)-metabolizing enzymes with therapeutic efficacy and adverse drug reactions (ADRs) in pediatric patients with lupus nephritis (LN). METHODS: A retrospective cohort study was conducted on 46 childhood-onset LN patients treated with CTX pulse therapy at Peking Union Medical College...

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