CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population.

doi:10.1097/FPC.0b013e32805b72c1

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Article

CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population.

Pharmacogenetics and genomics - 1 Jul 2007

Saito Yoshiro, Katori Noriko, Soyama Akiko, Nakajima Yukiko, Yoshitani Takashi, Kim Su-Ryang, Fukushima-Uesaka Hiromi, Kurose Kouichi, Kaniwa Nahoko, Ozawa Shogo, Kamatani Naoyuki, Komamura Kazuo, Kamakura Shiro, Kitakaze Masafumi, Tomoike Hitonobu, Sugai Kenji, Minami Narihiro, Kimura Hideo, Goto Yu-ichi, Minami Hironobu, Yoshida Teruhiko, Kunitoh Hideo, Ohe Yuichiro, Yamamoto Noboru, Tamura Tomohide, Saijo Nagahiro, Sawada Jun-ichi

Abstract excerpt

OBJECTIVE: CYP2C8 is known to metabolize various drugs including an anticancer drug paclitaxel. Although large interindividual differences in CYP2C8 enzymatic activity and several nonsynonymous variations were reported, neither haplotype structures nor their associations with pharmacokinetic parameters of paclitaxel were reported. METHODS: Haplotype structures of the CYP2C8 gene were inferred by an...

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PMID: 17558302
DOI: 10.1097/FPC.0b013e32805b72c1

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