Article
Parkinson's Disease-Associated Changes in the Expression of Neurotrophic Factors and their Receptors upon Neuronal Differentiation of Human Induced Pluripotent Stem Cells.
Journal of molecular neuroscience : MN - 1 Apr 2020
Novosadova E V, Nenasheva V V, Makarova I V, Dolotov O V, Inozemtseva L S, Arsenyeva E L, Chernyshenko S V, Sultanov R I, Illarioshkin S N, Grivennikov I A, Tarantul V Z
Abstract excerpt
Parkinson's disease (PD) is a neurodegenerative pathology resulting from the degeneration of dopaminergic (DA) neurons in the substantia nigra (SN). Neurotrophic factors (NTFs) and their receptors are key regulators of the survival, differentiation, and development of neurons. However, the role of these factors in the pathogenesis of PD is still unclear. Here, we analyzed the expression of NTFs and their...
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