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Article

NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP.

Neurobiology of aging - 1 Mar 2013

Yu Mei, Suo Haiyun, Liu Ming, Cai Lei, Liu Jie, Huang Yufang, Xu Jing, Wang Yancong, Zhu Cuiqing, Fei Jian, Huang Fang

Abstract excerpt

Parkinson's disease (PD) is characterized by progressing loss of dopaminergic neurons in the midbrain. Abnormal gene expression plays a critical role in its pathogenesis. Neuron-restrictive silencer factor (NRSF)/neuronal repressor element-1 silencing transcription factor (REST), a member of the zinc finger transcription factors, inhibits the expression of neuron-specific genes in nonneuronal cells, and regulates...

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Identifiers

PMID: 22766071
DOI: 10.1016/j.neurobiolaging.2012.06.002

Genes

REST
GFAP

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NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP.PMID 22766071Read ↗

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