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Article

Directed evolution of engineered virus-like particles with improved production and transduction efficiencies.

Nature biotechnology - 1 Oct 2025

Raguram Aditya, An Meirui, Chen Paul Z, Liu David R

Abstract excerpt

Engineered virus-like particles (eVLPs) are promising vehicles for transient delivery of proteins and RNAs, including gene editing agents. We report a system for the laboratory evolution of eVLPs that enables the discovery of eVLP variants with improved properties. The system uses barcoded guide RNAs loaded within DNA-free eVLP-packaged cargos to uniquely label each eVLP variant in a library, enabling the...

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Identifiers

PMID: 39537813
DOI: 10.1038/s41587-024-02467-x
PMCID: PMC12085157

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