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Article

Newly Developed CK1-Specific Inhibitors Show Specifically Stronger Effects on CK1 Mutants and Colon Cancer Cell Lines.

International journal of molecular sciences - 7 Dec 2019

Liu Congxing, Witt Lydia, Ianes Chiara, Bischof Joachim, Bammert Marie-Thérèse, Baier Joana, Kirschner Stefan, Henne-Bruns Doris, Xu Pengfei, Kornmann Marko, Peifer Christian, Knippschild Uwe

Abstract excerpt

Protein kinases of the CK1 family can be involved in numerous physiological and pathophysiological processes. Dysregulated expression and/or activity as well as mutation of CK1 isoforms have previously been linked to tumorigenesis. Among all neoplastic diseases, colon and rectal cancer (CRC) represent the fourth leading cause of cancer related deaths. Since mutations in CK1δ previously found in CRC patients...

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Source

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Identifiers

PMID: 31817920
DOI: 10.3390/ijms20246184
PMCID: PMC6941124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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