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Article

Cytological and genetic consequences for the progeny of a mitotic catastrophe provoked by Topoisomerase II deficiency.

Aging - 8 Dec 2019

Ramos-Pérez Cristina, Dominska Margaret, Anaissi-Afonso Laura, Cazorla-Rivero Sara, Quevedo Oliver, Lorenzo-Castrillejo Isabel, Petes Thomas D, Machín Félix

Abstract excerpt

Topoisomerase II (Top2) removes topological linkages between replicated chromosomes. Top2 inhibition leads to mitotic catastrophe (MC) when cells unsuccessfully try to split their genetic material between the two daughter cells. Herein, we have characterized the fate of these daughter cells in the budding yeast. Clonogenic and microcolony experiments, in combination with vital and apoptotic stains, showed that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31812950
DOI: 10.18632/aging.102573
PMCID: PMC6932922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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