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Analyzing Mitotic Chromosome Structural Defects After Topoisomerase II Inhibition or Mutation.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Giménez-Abián Juan F, Lane Andrew B, Clarke Duncan J

Abstract excerpt

For analyzing chromosome structural defects that result from topoisomerase II (topo II) dysfunction we have adapted classical cell cycle experiments, classical cytological techniques and the use of a potent topo II inhibitor (ICRF-193). In this chapter, we describe in detail the protocols used and we discuss the rational for our choice and for the adaptations applied. We clarify in which cell cycle stages each of...

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PMID: 29177744
DOI: 10.1007/978-1-4939-7459-7_15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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