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Article

Clinical significance of human immunodeficiency virus type 1 replication fitness.

Clinical microbiology reviews - 1 Oct 2007

Dykes Carrie, Demeter Lisa M

Abstract excerpt

The relative fitness of a variant, according to population genetics theory, is that variant's relative contribution to successive generations. Most drug-resistant human immunodeficiency virus type 1 (HIV-1) variants have reduced replication fitness, but at least some of these deficits can be compensated for by the accumulation of second-site mutations. HIV-1 replication fitness also appears to influence the...

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Identifiers

PMID: 17934074
DOI: 10.1128/CMR.00017-07
PMCID: PMC2176046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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