Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse Dux is myotoxic and shares partial functional homology with its human paralog DUX4

11 Sept 2016

Abstract excerpt

D4Z4 repeats are present in at least 11 different mammalian species, including humans and mice. Each repeat contains an open reading frame encoding a double homeodomain (DUX) family transcription factor. Aberrant expression of the D4Z4 ORF called DUX4 is associated with the pathogenesis of Facioscapulohumeral muscular dystrophy (FSHD). DUX4 is toxic to numerous cell types of different species, and over-expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Muscle Physiology and Disorders
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28173143
DOI: 10.1093/hmg/ddw287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse Dux is myotoxic and shares partial functional homology with its human paralog DUX4PMID 28173143Read ↗

Biphasic myopathic phenotype of mouse DUX, an ORF within conserved FSHD-related repeats.Semantic proximity Read ↗

DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesisSemantic proximity Read ↗

DUX4 Differentially Regulates Transcriptomes of Human Rhabdomyosarcoma and Mouse C2C12 CellsSemantic proximity Read ↗

DUX4 at 25: how it emerged from “junk DNA” to become the cause of facioscapulohumeral muscular dystrophySemantic proximity Read ↗

A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy.Semantic proximity Read ↗

Facioscapulohumeral dystrophy: activating an early embryonic transcriptional program in human skeletal muscleSemantic proximity Read ↗

<i>DUX4</i>, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53‐dependent myopathy in vivoSemantic proximity Read ↗

Antagonism among DUX family members evolved from an ancestral toxic single homeodomain proteinSemantic proximity Read ↗

Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.Semantic proximity Read ↗

Influence of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Possible TreatmentsSemantic proximity Read ↗

An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies.Semantic proximity Read ↗

Antagonism Between DUX4 and DUX4c Highlights a Pathomechanism Operating Through β-Catenin in Facioscapulohumeral Muscular DystrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.