Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anti-Nociceptive and Anti-Inflammation Effect Mechanisms of Mutants of Syb-prII, a Recombinant Neurotoxic Polypeptide.

Toxins - 1 Dec 2019

Li Chunli, Ban Mengqi, Bai Fei, Chen Jianzhao, Jin Xiaoquan, Song Yongbo

Abstract excerpt

Syb-prII, a recombinant neurotoxic polypeptide, has analgesic effects with medicinal value. Previous experiments indicated that Syb-prII displayed strong analgesic activities. Therefore, a series of in vivo and vitro experiments were designed to investigate the analgesic and anti-inflammatory properties and possible mechanisms of Syb-prII. The results showed that administered Syb-prII-1 and Syb-prII-2 (0.5, 1,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics
Share to Anti-Inflammatory Agents
Share to Edema

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Formaldehyde

Share to Ganglia, Spinal

Share to Mitogen-Activated Protein Kinases

Share to Neurotoxins

Source

Open in PubMed Open full text

Identifiers

PMID: 31805689
DOI: 10.3390/toxins11120699
PMCID: PMC6949983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anti-Nociceptive and Anti-Inflammation Effect Mechanisms of Mutants of Syb-prII, a Recombinant Neurotoxic Polypeptide.PMID 31805689Read ↗

Phenotypes and peripheral mechanisms underlying inflammatory pain-related behaviors induced by BmK I, a modulator of sodium channels.Semantic proximity Read ↗

The roles of conserved aromatic residues (Tyr5 and Tyr42) in interaction of scorpion toxin BmK AGP-SYPU1 with human Nav1.7.Semantic proximity Read ↗

A mutant of the Buthus martensii Karsch antitumor-analgesic peptide exhibits reduced inhibition to hNav1.4 and hNav1.5 channels while retaining analgesic activity.Semantic proximity Read ↗

Anemoside B4 alleviates neuropathic pain through inhibiting inflammationSemantic proximity Read ↗

Pronociceptive effects of nociceptin/orphanin FQ (13-17) at peripheral and spinal level in mice.Semantic proximity Read ↗

A Buthus martensii Karsch scorpion sting targets Nav1.7 in mice and mimics a phenotype of human chronic pain.Semantic proximity Read ↗

Geniposide alleviates neuropathic pain in CCI rats by inhibiting the EGFR/PI3K/AKT pathway and Ca2+ channelsSemantic proximity Read ↗

Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7.Semantic proximity Read ↗

Arginine residues in the C-terminal and their relationship with the analgesic activity of the toxin from the Chinese scorpion Buthus martensii Karsch (BmK AGP-SYPU1).Semantic proximity Read ↗

Diclofenac Sodium Nanomedicine Results in Pain-relief and Differential Expression of the RNA Transcriptome in the Spinal Cord of Spared Nerve Injury RatsSemantic proximity Read ↗

A TRPV1 agonist from the transcriptome profiling of Dipsastraea rotumana inhibits neuroinflammation in vivo through the NF-κB and MAPK pathwaysSemantic proximity Read ↗

iPSC-derived human sensory neurons reveal a subset of TRPV1 antagonists as anti-pruritic compoundsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.