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Article

The roles of conserved aromatic residues (Tyr5 and Tyr42) in interaction of scorpion toxin BmK AGP-SYPU1 with human Nav1.7.

International journal of biological macromolecules - 1 Jun 2017

Meng Xiangxue, Xu Yijia, Wang Fangyang, Zhao Mingyi, Hou Xue, Ma Yuanyuan, Jin Yao, Liu Yanfeng, Song Yongbo, Zhang Jinghai

Abstract excerpt

Scorpion toxins are invaluable source of therapeutic leads and pharmacological tools which produce influence on the voltage gated sodium channels. In the previous study, our group has reported BmK AGP-SYPU1 (64 amino acids), one scorpion toxin with both potential α-type and β-type scorpion characteristics and analgesic activity in vivo, act as an activator to hNav1.4 and hNav1.5. Additionally, conserved aromatic...

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PMID: 28065753
DOI: 10.1016/j.ijbiomac.2017.01.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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